Wang Resin Peptide Synthesis

Introduction to Features of Wang Resin for Peptide Synthesis

Among all the resins used in solid phase peptide synthesis, Wang resin is a widely used one to prepare peptides with Fmoc amino acids. The ester anchor of Wang resin can be easily achieved and stay in a stable format under different reaction conditions; in addition, with mild acid treatment (TFA - trifluoroacetic acid recommended), it can also be effortlessly cleaved to cater to various research needs. Because of this characteristic, Wang resin is also popular in solid phase organic synthesis. 

The development of Wang Resin

Using wang resin peptide synthesis can be easily achieved. So when was this resin first introduced, by who and under what circumstances? p-alkoxybenzyl alcohol resin, also known as Wang resin, was firstly developed in 1973. At that time, the method of solid phase peptide synthesis had been introduced, which resulted in the great increase with regard to synthesis efficiency. However, it was quite hard to purify the final products obtained through this technique. Su-sun Wang published his article p-Alkoxybenzyl alcohol resin and p-Alkoxybenzyloxycarbonylhydrazide Resin for Solid Phase Synthesis of Protected Peptide Fragments in 1973 which largely improved the yields and purity for solid phase peptide synthesis by using this resin and therefore people named it after Wang to honor his great contribution in the peptide synthesis resin innovation. Wang resin has become an inseparable element in peptide synthesis resin since then.

Fmoc (fluorenylmethoxycarbonyl protecting group), a base-labile protecting group, is widely applied in peptide synthesis with wang resin in that the esterification of Wang resins with fmoc amino acids can be challenging chemically. Although it is a popular solid phase peptide synthesis resin, chemists still prefer to use preloaded resins and they can be found on Applied Polytech’s product page as well. We are supplying a vast selection of Fmoc-Amino Acid attached to wang resin. The resins prepared at Applied Polytech are from 100-200 mesh size and consist of 1% cross-linker (DVB) polystyrene beads.

Here is a full list of preloaded resins with fmoc-amino acid attached to wang resins:

Fmoc-Ala-Wang Resin, Fmoc-D-Ala-Wang Resin, Fmoc-Arg(Pbf)-Wang Resin, Fmoc-Asn(Trt)-Wang Resin, Fmoc-Asp(OtBu)-Wang Resin, Fmoc-Cys(Acm)-Wang Resin, Fmoc-Cys(Trt)-Wang Resin, Fmoc-Gln(Trt)-Wang Resin, Fmoc-Glu(OtBu)-Wang Resin, Fmoc-Gly-Wang ResinFmoc-His(Trt)-Wang Resin, Fmoc-D-His(Trt)-Wang Resin, Fmoc-Ile-Wang Resin, Fmoc-Leu-Wang Resin, Fmoc-Lys(Boc)-Wang Resin, Fmoc-Met-Wang Resin, Fmoc-Phe-Wang Resin, Fmoc-Phe(4-Cl)-Wang Resin, Fmoc-Phe(4-F)-Wang Resin, Fmoc-Phe(4-NO2)-Wang Resin, Fmoc-Pro-Wang Resin, Fmoc-Ser(tBu)-Wang Resin, Fmoc-Thr-Wang Resin, Fmoc-Thr(tBu)-Wang Resin, Fmoc-Trp-Wang Resin, Fmoc-Trp(Boc)-Wang Resin, Fmoc-Tyr(tBu)-Wang Resin, Fmoc-Val-Wang Resin, Fmoc-1-Nal-Wang Resin, and Fmoc-2-Nal-Wang Resin.

Buy Wang resin for peptide synthesis at the best price with Applied Polytech. We also offer pre-loaded resins like Fmoc-Amino Acids attached to Wang Resins. A full list of pre-loaded resins is provided above.  Place your order online to buy Wang resin in bulk quantities or for lab uses. We are here to serve and provide products that best suit your needs! For more details or any product inquiries, contact us at info@appliedpolytech.com and we are happy to answer any of your questions!