Peptide Synthesis Resin/Resin for Peptide Synthesis

 

Overview of peptide synthesis

Resin is, in polymer chemistry, a solid substance of synthetic origin that can be converted to polymers. Usually they are mixtures of organic compounds. Resins can normally be created in a lab by organic synthesis process. Thanks to Merrield’s outstanding contribution to the development of peptide synthesis chemistry in 1963, the speed of peptide synthesis has been tremendously improved after the introduction of solid phase synthesis.

Polystyrene resin has a long history serving as a base resin for preparing various resin in solid phase peptide synthesis and it is convertible to other more versatile supports by linking with different groups. With over 50 years of development in solid phase peptide synthesis resin manufacturing process, people are able to supply many different kinds of high quality resin for both industrial and laboratory use.

As is known to all, amino acids are the structural units for the proteins supporting our body functions. Peptides are formed when those acids linking together in short polymer chains and polypeptides or in other words proteins are formed when those chains are longer. 

In chemistry, peptide synthesis is a process of peptide production. During this process, multiple amino acids are linked together via peptide bonds. In other words, peptide synthesis is essentially the formation of a peptide bond between the two carboxyl groups of amino acids1, even though peptide is made in the opposite direction in nature. Peptide synthesis plays a crucial role in today’s biochemical, pharmacological, immunological and biophysical laboratories.

Amino acid addition consists of cleavage of the Nα-protecting group, washing, coupling of a protected amino acid and washing. The first step in peptide synthesis is having an amino-protected amino acid bound to a resin. After the amino group is deprotected, it reacts with the carbonyl group of the next amino acid. A peptide chain is formed after repeating this process. To avoid side reactions with undesirable amino acid, various protecting groups are introduced in solid phase peptide synthesis. 

Resin for peptide synthesis

Traditionally, this chemical synthesis process was conducted by using solution-phase techniques; however, the method of solid-phase peptide synthesis was found to allow assembly of peptide chain over hundred times faster than solution phase peptide synthesis and has now taken over the position and becomes the most widely used techniques in today’s research and development settings2. Peptide synthesis resin is small beads functionalized with different groups. 

Speaking of resin for peptide synthesis, how to choose one with the right functionality for peptide synthesis is crucial. It appears that due to the variety of commercially available resin for peptide synthesis, it has become a babel for not only novice researchers but also experienced practitioners when it comes to peptide synthesis resin selection. The most commonly used solid phase peptide synthesis resin is cross-linked polystyrene. A good solid support (resin) for SPPS must be stable and allow rapid filtration of fluids. The specification of linkers can be as crucial as solid support in solid phase reaction optimization because they have to be compatible with all the synthesis and remain liable under cleavage conditions that do not cause decomposition of the compounds generated in the library3. Resin for peptide synthesis Applied Polytech is selling all have 1% cross linker (DVB), which is optimal for solid phase peptide synthesis. We offer size distribution 30-70 mesh, 70-90 mesh, 100-200 mesh, and 200-400 mesh with various loadings. With our peptide synthesis resin, you can achieve not only high efficiency and throughput, but also increased simplicity and speed for solid phase synthesis. 

Our line of products

Applied Polytech offers high-quality peptide synthesis resin in various particle sizes and loading to meet your different research demands. Our line of products includes most commonly used solid phase peptide synthesis resin: Wang Resin, Aminomethyl Resin, MBHA Resin, Rink Amide Resin, Rink Amide-AM Resin, Rink Amide-MBHA Resin, 2-Chlorotrityl Chloride Resin, Merrifield Resin, Macroporous Chloromethyl Resin, PAM Resin, Hydroxymethyl Resin, Sieber Resin and more!

As a wholesale supplier, we are aiming to cut unnecessary cost in the supply chain but never to compromise our product quality. Your success is assured by a group of scientists and engineers specializing in GMP and Lean Six Sigma manufacturing. Our resin is among the highest quality in the North America market. 

We are here to help thousands of scientists to fight COVID-19 and we are currently offering a 10% discount for first time customers! Seize the opportunity and visit our product page now to buy resin for peptide synthesis at a reasonable price! Let us become your most reliable research partner!

 

1 Isidro-Llobet A, Alvarez M, Albericio F (June 2009). "Amino acid-protecting groups" (PDF). Chemical Reviews. 109 (6): 2455–504. 

2 Jaradat, Da’san M. M. (28 November 2017). "Thirteen decades of peptide synthesis: key developments in solid phase peptide synthesis and amide bond formation utilized in peptide ligation". Amino Acids. 50 (1): 39–68.

3 Bunin, Barry A. (2012). LINKERS FOR SOLID-PHASE SYNTHESIS, The Combinatorial Index, 2012, Pages 9-76.