2-Chlorotrityl Chloride Resin
2-Chlorotrity chloride resin is slightly less acid-labile than Trityl Resin and thus more widely used in solid phase peptide synthesis. This resin has been also widely used in solid phase organic synthesis by immobilizing carboxylic acid, alcohols, phenols, amines, imidazoles, hydroxylamines, and thiols on it. Cleavage is achieved using AcOH/TFE/DCM, 0.5% TFA or HFIP in DCM, or 1-5% TFA in DCM containing 5% TIS. Trityl linkers have certain advantages in comparison to the alkoxybenzyl alcohol (eg. Wang resin), especially in the area of peptide chemistry. First, the problem of racemization during the loading of the first amino acid (using DIPEA) is avoided with trityl linkers. Second, due to steric factors, no diketopiperazine formation is observed.
Product Specification
Product #
Cross Linker (DVB)
Particle Size
(mesh)Loading (mmol/g)
25g
100g
500g
20181810
1%
100-200
0.4-1.0
$95
$285
$925
20181811
1%
100-200
1.0-1.6
$95
$285
$925
20181812
1%
200-400
0.4-1.0
$95
$285
$925
20181813
1%
200-400
1.0-1.6
$95
$285
$925