Hydroxymethyl Resin

Hydroxymethyl Resin

$30.00Price

This resin is ideal for the solid phase immobilization of carboxylic acids. During the attachment of diacids less cross-linking is observed in comparison to Merrifield resin. Reaction with a suitable phosgene equivalent converts this resin to a support suitable for the immobilization of amines. The carbamate linker of hydroxymethyl polysterene can be used as an equivalent of Cbz, is stable to a wide range of acidic, basic and reductive conditions. Fisher indole synthesis and Pictet-Spengler cyclization on solid support, which require 70ºC in acetic acid with zinc cloride and 10% TFA in dichloromethane, respectively, were successfully carried out using this linker. Methyl esters can be produced by transesterification with MeONa or Ti(OEt)4/C2H5CO2Me. Carboxamides are also accessible via Lewis acid catalyzed aminolysis. Highly pure ketopiperazines can be produced by the resin-bound alpha-amino acids.

  • Product Specification

    Product #

    Cross Linker (DVB)

    Particle Size
    (mesh)

    Loading (mmol/g)

    5g

    25g

    100g

    15081820

    1%

    70-90

    0.5-1.5

    $30

    $85

    $205

    15081821

    1%

    100-200

    0.5-1.5

    $30

    $85

    $205

    15081822

    1%

    100-200

    1.5-3.0

    $30

    $85

    $205

    15081823

    1%

    200-400

    0.5-1.5

    $30

    $85

    $205

    15081824

    1%

    200-400

    1.5-3.0

    $30

    $85

    $205